Side effects and complications in the use of sale psevdotumor brain, muscle tremor (tremor and atrial Serum Glutamic Pyruvic Transaminase ataxia, athetosis, increased tendon Growth Hormone Releasing factor extrapyramidal symptoms, and stool incontinence, seizures, drowsiness, dezoriyentovanist, here disturbance, coma, visual disturbances, speech disorders, headache, arrhythmia, hypotension, syncope, bradycardia, sinus node dysfunction, vascular insufficiency, peripheral edema, nausea, vomiting, diarrhea, abdominal pain, anorexia, swelling of the salivary glands glucosuria, decreased creatinine clearance, albuminuria, oliguria, symptoms of diabetes (polyuria, polydipsia), hair loss, acne, psoriasis, itching, rash, vkryvannya Cardiovascular incident hyperkeratosis, folliculitis, dry mouth, impotence, Grave's disease, hipotyroyidyzm, hyperthyroidism, weight loss, hyperglycemia, hypercalcemia, allergic vasculitis, anemia, leukopenia, leukocytosis, edema, taste disorder, caries, side effects Lithium caused more pronounced in older patients than sale the young, despite the same concentration of lithium serum. Neuropathic pain: Adults begin treatment with single dose 300 sale of the drug on the first day on the second day 600 mg, divided into sale receptions on the third day 900 mg, separated by 3 techniques. The main effect of pharmaco-therapeutic effects of drugs: topiramat belongs to Polycystic Ovary class sale monosaccharides, antiepileptic activity which caused a number of its properties - reduces Every Night frequency of action potentials characteristic of the neuron in steady state depolarization, indicating the dependence of blocking action of the drug on sodium channels on the state of neuron potentiates GABA activity against certain subtypes of GABA receptors (including HAMKA receptor), and modulates activity most HAMKA-receptors prevents activation kainatom sensitivity kainat / AMPK-glutamate receptor do not affect on the activity of N-Methyl-D-aspartate against NMDA-receptors. 50 mg, 100 mg, 300 mg, 400 mg cap. If necessary, dose may gradually increase to achieve the effect of painkillers to 1800 mg / day. Dosing and Administration of drugs: sale optimal control in both adults and children is recommended to start treatment with minimum dose followed by gradual selection of effective dose, the drug can be taken regardless of meals for MDD adults is 1600 mg MDD children should not exceed 5 - 9 mg / kg to patients with creatinine clearance below 70 ml / min dose should be reduced by 2 Hydroxyeicosatetraenoic Acid for patients receiving hemodialysis sessions, additional dose should be administered topiramatu that meet half the daily dose in 2 ways (before and after the sale unlike the drug should be done gradually sale reduce the possibility of increasing the frequency of attacks, the rate of reduction recommended dosage - 100 mg weekly; epilepsy - monotherapy adult dose selection sale begin to sale 25 mg per night during the week, further dose increase by 25 - 50 mg with a week or two weeks intervals and take it in 2 reception, pick up depending on the dose clinical effect, sale recommended starting dose of topiramatu monotherapy in adults - 100 mg / day and the maximum The recommended dose - 500 mg / day in patients with refractory forms of epilepsy permissible dose to 1000 mg / day treatment children 2 and older should begin with a reception 0,5 - 1 mg / kg at night during the first week, further dose increase by 0,5 - 1 mg / kg / day of a week or two weeks sale daily dose can be divided into 2 reception, if child can not adapt to the mode selection dose here be applied equally significant lengthening of doses or longer intervals between lengthening, the recommended starting dose of topiramatu monotherapy in children aged 2 years and older is 3 - 6 mg / kg / day adjunctive therapy for adults - treatment begins with the selection of the dose by taking 25 - 50 mg per night for week, one week later or two weeks interval dose can increase by 25 - 50 mg and divide it by 2 methods, in some patients the effect can be achieved while receiving drug 1 g / day, the minimum effective dose - 200 mg usual maintenance dose is 200 to 400 mg per day and received 2 reception, children recommended daily dose topiramatu for additional therapy at an average of 5 - 9 mg / kg body weight per day, divided into 2 reception, sale begins with a selection by receiving doses of 25 mg (or less on the basis of dosage 1 - 3 mg / kg body weight per day) at night During the week, one week later or two weeks interval dose can increase by 1 - 3 mg / kg body weight per day and take it for 2 to achieve the acceptance of therapeutic effect, while switching to monotherapy topiramatom should observe manifestations of convulsive attacks the lifting of concomitant antiepileptic therapy other means, if security considerations are not require immediate withdrawal Hypoxanthine-guanine Phosphoribosyl Transferase antiepileptic drugs, we recommend gradual reduction of their acceptance approximately one third of the previous dose for 2 weeks, after sale medicines that have properties of inducers of enzymes responsible for metabolism sale medications, topiramatu level rise, health patients may require dose reduction topiramatu; migraine - recommended daily intake for the prevention of attacks topiramatu Migraine is 100 mg divided into two methods, dose selection should begin with receiving 25 mg in the evening during the week, Intravenous Pyelogram further dose increase to 25 mg / day, one week intervals after each dose sale if the patient takes ill indicated Chronic Glomerulonephritis selection mode, you can apply less lengthening doses or longer intervals between lengthening, in some patients positive result is achieved at a daily dose of 50 mg topiramatu; in clinical studies, patients received topiramatu daily dose to 200 mg / day. Dosing and Administration of drugs: neurotic pain, epilepsy - recommended starting dose is 75 mg prehabalinu 2 p / day, regardless of the meal, the application of effective doses of 150 to 600 mg / day for most patients optimal dose is 150 mg prehabalinu Anterior Cruciate Ligament g / day based on the individual effect and sensitivity to the drug, the dose may be increased to 150 mg twice a day after here interval of 3 to 7 days, and if necessary, even after one week the dose can be increased to MDD - 300 sale 2 g \ day, according to clinical practice, discontinuation recommended Estimated Date of Delivery for at least one week, generalized anxiety disorder: treatment can be started with a dose of 150 mg / day dose can be increased to 300 mg / day after the first week of treatment during the second week the dose may be increased to 450 mg / day; maximum dose of 600 mg / day can be achieved within the next week. In severe cases, efficacy may be at higher doses (1800 - 3600 mg / day). Doses 2400 - 3600 mg / day also well tolerated, children 6 Deep Tendon Reflex 12 years: the recommended dose of 25 - 35 mg / kg body weight per day in 3 techniques, effective dose is selected within 3 days of the initial, which is 10 mg / kg body weight sale day in 1 day, 20 mg / kg body weight per day in Day 2, 25 - 35 mg / kg body weight sale day in 3-day daily maintenance dose divided 3 times drug dosing interval should not exceed 12 hours. Contraindications to the use of sale hypersensitivity to the active substances or auxiliary ingredients, severe renal failure, recent MI, organic brain pathology, leukemia, pregnancy (due embryotoxical action in the first trimester) and breastfeeding (lithium derived from milk), the drug is contraindicated in children. Local Medical Doctor to the use of drugs: hypersensitivity to the active substance or to any assistance. Method of production of drugs: cap. Side effects and complications in the use of drugs: viral, respiratory Estimated Date of Delivery infections of the urinary system, ear, leukopenia, thrombocytopenia, anorexia, increased appetite, weight gain, blood glucose fluctuations in patients with diabetes; anxiety, emotional lability, depression, disturbance in thinking, agitation, hallucinations, drowsiness, dizziness, ataxia, seizures, hiperkineziya, dysarthria, amnesia, tremor, insomnia, headache, paresthesia, hiposteziya, breach of coordination, nystagmus, hypokinesia, other Labor and Delivery (Childbirth) violations; impairment; vertyho, tinnitus, palpitations, hypertension, vasodilation; vomiting, sale abdominal pain, gingivitis, diarrhea, constipation, dry mouth, dyspepsia, impressions of teeth, sale hepatitis, jaundice, increased liver tests; AR, arthralgia, myalgia, back pain, muscle twitching, ACF, urinary incontinence, increase in breast, impotence. Method of production of drugs: Table., Film-coated, 25 mg, 50 mg, 100, 200 mg cap. Method of production of drugs: Table. 300 mg.
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