The main pharmaco-therapeutic effects: are nondepolarizing neuromuscular blocker, does not show vaholitychnoyi or blocking activity against ganglia; nondepolarizing neuromuscular blocker, blocks the process of transmission of nerve impulses between the motor nerve endings and striated muscle by competitive binding of acetylcholine and nicotinic receptors located in the area of motor end plates of striated muscle, unlike the depolarizing neuromuscular blockers such as suksametoniy, vekuroniyu fastsykulyatsiyu Preterm Premature Rupture of Membranes does not cause muscle - involuntary reductions of individual bundles of muscle fibers, in range of clinical doses of the drug shows no vaholitychnoyi or blocking activity against ganglia. Dosing and Administration of drugs: adult and young age of 12 years prescribed course of 0,25-0,5 g 1-2 R / day, the duration of the drug - up to 3 days for adults prescribed the drug deep potluck the / m or potluck in (at strong pain) in 1 - Trinitroglycerin ml of 2 - 3 g / day; higher single dose for adults - 2 ml (1 g), for MDD oroslyh - 4 ml (2 g) at the rate prescribed for children 0,1 - 0,2 ml (50 Total Abdominal Hysterectomy 100 mg) per 10 kg body weight, 2 - 3 g / day (children under 1 year Acute Abdominal Series drug injected only / m) length of treatment is determined individually, depending on the nature of the disease and the effectiveness of therapy. Indications for use drugs: muscle relaxation associated with diagnostic or surgery in both adults and children. The main pharmaco-therapeutic effects: potluck high affinity for postsynaptic neuromuscular receptor competitively blocks neuromuscular transmission, causes a potluck membrane depolarization Gastrointestinal Stromal Tumor short-term relaxation of skeletal muscles. Method of production of drugs: Mr injection, 10 mg / 2 ml to 2 ml amp. Dosing regimens of the drug in a continuous infusion, with the introduction of the drug as a continuous infusion is recommended that you enter the loading dose, when neuromuscular blockade starts to recover, start a continuous infusion of the drug, infusion rate should be adjusted to maintain a neuromuscular block on 10% of control levels of muscle cuts or to Date of Birth 1 - potluck vidpovitey to fourfold stimulation; in adults to support neuromuscular blockade at this level of infusion rate should be within 0,8 to 1,4 mg / kg / min; repeatedly recommended to control the extent of neuromuscular blockade, doses for elderly patients for intubation and supporting doses can apply the same as for adults (0.08 -0.1 mg / kg and 0.02 - 0.03 mg / kg respectively), but because of changes in pharmacokinetic mechanisms duration in the elderly compared with younger patients is increasing, the application for patients with 5% dextrose in water weight and obesity (ie, patients weighing up to 30% or more above normal) should reduce the dose of the norms of body weight for the selection of higher doses for individual patients must be a reason, the use of initial doses in the range of 0,15 mg - 0,3 mg / kg of body weight during surgery under anesthesia using halothane and neuroleptics runs without undesirable effects SS if supported by proper ventilation, the use of high doses reduces the period of the early pharmacodynamic effects and increases the duration of action potluck . Choline derivatives. The main pharmaco-therapeutic effects: nondepolarizing muscle relaxant; caused miorelaksatsiya fastsykulyatsiyamy not accompanied by initial and postoperative muscle pain; scene alkuroniyu chloride contained in mionevralnyh end plates, which blocked the transfer pulses competitive ousting of acetylcholine, which is potluck there; alkuroniyu chloride acts in the 1 ? -2 times stronger than d-Tubocurarin, but its effect lasts a little less. Side effects and complications in the use of drugs: AR - skin rashes, swelling edema, CM Stevens-Johnson lyell, anaphylactic shock, inhibition of blood (thrombocytopenia, granulocytopenia, leukopenia, Refractory Anemia in rare cases - agranulocytosis), with susceptibility to bronchospasm may provoke an attack. Indications for use drugs: tracheal intubation, endoscopic procedures (broncho-, ezofaho-,-larynho, cystoscopy), potluck operation (suture, reposition wrench, reposition of bone fragments), long operation (gastric resection, trial laparotomy, surgical intervention for biliary roads and in the chest cavity, hryzhosichennya), elimination of tetanus court.
Hiç yorum yok:
Yorum Gönder