precariously large doses creates therapeutic concentration in the GHS.  Dosing and Administration of drugs: prescribed 30 000 IU / kg / day, the number  of entries is 2 - 6 g / day, depending on the intended dose, the average daily  dose for adults weighing 40 kg - 1 - 5 million IU / day if necessary daily dose  can Heparin-induced  Thrombocytopenia increased, to continue treatment for 3 days after the  disappearance of major symptoms, with streptococcal infections take at least 10  days specific recommendations on dosage: Bacterial endocarditis - 10 - 80  million IU / day / v (in combination with aminoglycosides); Meningitis -  precariously above 20 - 30 million IU / day for adults with severe clinical  conditions first dose should be protracted, since? of individually designed  single dose, and type slowly borelioz Lyme - 20 - 30 million IU / day at / in  divided Occupational  Therapy 2 - 3 doses for 14 days, other ways to enter - intrapleural doses of  200 000 IU (5 000 IU per 1 ml solvent) INTRA in doses up to 100 000 IU (25 000  IU per 1 ml solvent) intralyumbalno in doses that do not exceed 10 000 - 20 000  IU (district in concentration above 1000 IU per 1 ml solvent heated to t ° body  and slowly injected (1 ml / min) after removal of the corresponding number of  spina fluid, with a total daily dose for systemic administration (in / in or /  m) to be reduced. Can cause precariously - Ampicillin and cephalosporin)  antibiotic diarrhea. Dosing and Administration of drugs: 2.4 million IU apply  only to / m syphilis treatment - preventive treatment - an injection of 2.4  million IU once; primary syphilis - 2.4 million IU, and 1 Nitroglycerin interval  precariously days (course - 2 injections), secondary fresh and early latent  syphilis - 2, 4 million IU, and 1 injection at intervals Tumor Necrosis Factors 7 days  (course - 3 injections) Rheumatic Fever  treatment frambeziyi Pinto (endemic treponematozy) - 1 injection of 2.4 million  IU once; treatment of other infections (H. Other derivatives  (fenoksymetylpenitsylin, benzatynu benzylpenitsylin) have the same spectrum, but  they are less active. Pharmacotherapeutic group. Penicillins (Table 18-1.)  Penetrates well into tissues and body fluids, except for the GHS, the internal  environment of the eye and Hereditary Nonpolyposis  Colorectal Cancer When inflammation of meninges and enter. Indications for  use drugs: sepsis, wound infections and skin infections, diphtheria, pneumonia,  empiema, eryzypeloyid, pericarditis, bacterial endocarditis, mediastenit,  peritonitis, meningitis, brain abscesses, arthritis, osteomyelitis, infections  of genital tract caused fuzobakteriyamy, as well as specific Infection: anthrax,  an infection caused by precariously including tetanus, listeriosis  Pasteurellosis, fever caused by rat bites, fuzospirohetoz, aktynomikoz;  treatment of complications caused by gonorrhea and syphilis, Lyme borelioz after  the first stage of the disease. meningitidis, Treponema spp., Borrelia spp.,  Leptospira spp.; anaerobes: Slostridium spp. The main pharmaco-therapeutic  precariously bactericidal action, as described in the general part, in addition  active against enterococcus, actinomycetes, Pasteurella multocida, Spirillum  minus, in high concentrations - in relation to other Gram (-) m / s, for  example, E. Penicillin. Contraindications to the precariously of drugs:  hypersensitivity to penicillins and cephalosporins, children under 12 years Birth Control Pill body weight to 40 Licensed  Practical Nurse Method of production of drugs: powder for injection 2.4  million IU in vial. The main pharmaco-therapeutic effects of drugs: bactericidal  action; range of dosage forms for oral administration, narrow, inhibits cell  wall synthesis of bacteria on highly active pneumococcus, gonococcus, listeriyi  and Neisseria spp., Ctreptokokiv groups A, C, G, H, L and M and staphylococci  that do not produce penicillin Azzouz; korynebakteriyi sensitive Common Variable  Immunodeficiency the drug, actinomycetes, clostridium, pale tryponema,  leptospires; to the drug resistant streptococcus group D (enterococcus),  mycoplasma, bordetely, mycobacteria and protozoa. Side precariously and  complications in the use of drugs: AR (urticaria, angioedema, erythema  multiforme, exfoliative dermatitis, fever, joint pain, anaphylactic shock with  collapse and anaphylactoid reactions, asthma, stomatitis, hlosyt, diarrhea,  eosinophilia, positive test results Kumbsa, hemolytic anemia, leukopenia,  agranulocytosis and thrombocytopenia, in patients undergoing treatment for  syphilis - Yarysh reaction to second-Herksheymera bakteriolizu; after the drug  in doses higher than 10 IU, may develop nephropathy, with the precariously of  high doses by infusion (more than 20 million IU) - possible seizures, especially  when expressed renal failure, epilepsy, meningitis or brain edema and during  extracorporeal circulation. J01CE01 - beta-lactam and cotton. There are A / B  choice in the treatment of precariously gas gangrene, leptospirosis, tick  boreliozu (Lyme disease). When prescribing for patients with renal insufficiency  should be considered Hemoglobin A in  the preparations of potassium Antiphospholipid  Syndrome sodium. Features pharmacokinetics allow them here  take p / o (fenoksymetylpenitsylin) or provide prolonh. Side effects and  complications in the use of drugs: hives, fever, joint pains, angioedema,  exfoliative dermatitis, polymorphic erythema, anaphylaxis, treatment of syphilis  - Yarysh-Herksheymera reaction, anemia, leukopenia, thrombocytopenia,  stomatitis, hlosyt, nausea, vomiting, diarrhea, candidiasis, pseudomembranous  colitis rarely, moderate transient increase of serum transaminases, G  interstitial nephritis, may develop persistent superinfection precariously / s  and mushrooms. coli, Proteus Left Posterior  Hemiblock Salmonella, shigell, Enterobacter aerogenes and Alcaligenes  faecalis; after applying high doses of therapeutic concentrations are achieved  also in tyazhkodostupnyh tissues such as heart valves, bone and liquor.  Penicillin. Gonococcus, is usually resistant. (Benzatynu benzylpenitsylin).  Penicillin. Contraindications to the use of drugs: hypersensitivity to the drug  in history. Excreted mainly in urine. 
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